MSc positions at Univ Medical Center Ulm

The Department of Internal Medicine III (Hematology, Oncology, Rheumatology, and Infectious Diseases) at the University Medical Center Ulm offers a highly interactive and collaborative scientific environment with a strong focus on translational oncology research.

Ph.D. studentship (MSc) positions are available in the laboratories of Lars Bullinger (http://www.uniklinik-ulm.de/index.php?id=10705), Florian Kuchenbauer (http://www.uniklinik-ulm.de/news/article/1119/ulmer-leukae.html) and Daniel Mertens (http://www.mertens-lab.de). The positions are  limited to 2 years and can be filled immediately. A subsequent extension of employment is possible.

Research foci are:

• Several challenging projects focusing on the role of epigenetics or miRNAs in leukemogenesis, interaction of leukemic cells with their microenvironment, and "omics" and next-generation sequencing based molecular characterization of leukemia:

Lars Bullinger: genomic and epigenomic profiling in acute myeloid leukemias
Florian Kuchenbauer: non-coding RNAs in normal and aberrant hematopoeisis
Daniel Mertens: epigenetics, microenvironment and miRNAs in leukemogenesis

• For project details please see the websites or contact the supervisors directly (see below).

Your personal profile:

• We are looking for a highly motivated, team-minded candidate with a strong interest in science. You will join an international research group working on the molecular mechanisms that cause leukemias and lymphomas.
• Applicants should hold a degree in biology, biochemistry, genetics, or a related field and have excellent laboratory and analytical skills.
• Experiences in molecular biology of cancer, epigenetics, ncRNA or systems biology are a plus.

We offer:

• Payment based on TV-L
• Multifaceted and challenging tasks
• Working environment in an international team
• Compatibility of career and family

Full applications can be send via the online-application-portal of the University Medical Center Ulm (www.uniklinik-ulm.de/stellenangebote, currently the portal is only in German available) or via e-mail to the following address: service.recruiting@uniklinik-ulm.de.
Please mention the reference code 100326 in your application.

If you have further questions concerning the several projects, please send them via e-mail directly to

• lars.bullinger@uniklinik-ulm.de,
• florian.kuchenbauer@uni-ulm.de or
• daniel.mertens@uniklinik-ulm.de.

Closing date for applications: 15th May 2011

Contact: Eva-Maria Karremann, Recruiting, Tel: (+49) 731 500-66464

The University Ulm aims to increase the proportion of women and therefore encourages qualified female scientists to submit their applications.

In general, full-time positions are divisible.
Handicapped people, especially handicapped women, with equal qualifications will be employed and trained preferentially.
Employment takes place through the administration department of the University Medical Center Ulm in the name and on behalf of the federal state of Baden-Württemberg.
 

PhD position in molecular biology at Medical Univ of Vienna

A PhD position is available immediately at the Medical University of Vienna. The project, funded by the Austrian Science Fund, studies structure and function of the human ABC-transporter P-glycoprotein (ABCB1) as a paradigm for ABC-exporter function (for further information see: www.fwf.ac.at, grant P23319). ABCB1 is a major determinant of the response of human disease to systemic pharmacotherapy. The project aims at developing a model of P-glycoprotein transport function at atomic resolution.

Applicants must hold a master degree with a strong background in molecular biology. We are looking for highly motivated candidates of all nationalities who have a keen interest in our research topic. Our project is conducted in the multidisciplinary environment of a research cluster with a focus on membrane transporters. In order to take advantage of this environment we expect and encourage an explorative attitude and good communication skills, especially in English. Applicants should be familiar with standard molecular biology techniques (site directed mutagenesis, cloning techniques, expression systems). A background in computational biology is preferred. The position will receive funding from FWF for a period of three years.

The Institutes of Pharmacology and Medical Chemistry are located in vicinity of the historic center of Vienna and the teaching hospital of the Medical University of Vienna.

Applications containing a cover letter explaining relevant work experience, CV, copies of certificates and contact details of two references should be sent to: thomas.stockner@meduniwien.ac.at; peter.chiba@meduniwien.ac.at

PhD project title: Molecular Neurobiology of Circadian Timekeeping

Applications invited from EU & UK nationals for a fully funded 3-year PhD studentship under the supervision of Dr Michael Hastings FRS.

The aim of this project is to investigate the role of Cryptochrome proteins in the circadian timing machinery of mammals. Particular emphasis will be placed on their putative role as magnetoreceptors. Techniques to be applied include real-time bioluminescent and fluorescent imaging of circadian gene expression, cell and brain slice organotypic culture, recombinant protein biochemistry, targetted mutagenesis, virally mediated, optogenetic control of cellular activity, and proteomic analysis of circadian transcriptional complexes. How do Cryptochrome proteins behave within the cell over the 24 hour circadian cycle, what is their role in transcriptional regulation and how are their functions affected by magnetic fields?

The position will suit an industrious, highly motivated molecular neurobiologist/ biochemist with a track record of academic excellence. The successful applicant will work within an internationally renowned research group, headed by Dr Michael Hastings FRS, investigating various aspects of circadian timekeeping. The group is supported by the world-class facilities of MRC Laboratory of Molecular Biology. As a PhD student at LMB, the student will also become a member of a Cambridge College and be registered at the University of Cambridge.

References:

General:
Reppert, S.M., and Weaver, D.R. (2002). Coordination of circadian timing in mammals. Nature 418, 935-941

Hastings MH, Reddy AB, Maywood ES. (2003) A clockwork web: Circadian timing in brain and periphery, in health and disease. Nature Reviews Neuroscience 4: 649- 661.

Specific:
Gegear, R.J., Casselman, A., Waddell, S., and Reppert, S.M. (2008). Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature 454, 1014-1018.

Gegear, R.J., Foley, L.E., Casselman, A., and Reppert, S.M. (2010). Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism. Nature 463, 804-807.

Godinho, S.I., Maywood, E.S., Shaw, L., Tucci, V., Barnard, A.R., Busino, L., Pagano, M., Kendall, R., Quwailid, M.M., Romero, M.R., et al. (2007). The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316, 897-900.

Funding:
3 years PhD position for UK or EU national
Available for October 2011 Entrance
Fully funded for Fees and Maintenance at standard MRC (Home Student) rates

Application deadline: 31 May 2011

How to apply:
For further details and instructions on how to apply, please see the following webpage:
http://www2.mrc-lmb.cam.ac.uk/students/international-phd-programme/applications/projects/michael-hastings-oct2011

Interviews: To be held during week beginning 13 June 2011.

The successful applicant will need to apply to the University of Cambridge no later than 30 June 2011 once the PhD position has been confirmed: instructions will be given at time of PhD offer.

PHD position Promoter research for Chinese Hamster Ovary Cells

PHD position Promoter research for Chinese Hamster Ovary Cells

Deadline 15.05.2011
Ref.No. 11_2011
Apply to jobs@acib.at

The Austrian Centre of Biotechnology (ACIB, www.acib.at) in Vienna has a long term programme on optimization of Chinese Hamster Ovary cells and their use in biotechnological production of therapeutic proteins. In the current project the genetic information of the cells that is available to BOKU should be integrated used to identify and characterize andogenous promoters of CHO cells, specifically those that are highly expressed and / or regulated. Within the project, identified promoters will be cloned and characterized on model culture systems and potentially in bioprocesses. ACIB is seeking PhD candidate in the field of biotechnology / molecular biology / cell biology. A background in bioinformatics is of advantage.

Please send your application documents (inlcuding reference number) via e-mail to jobs@acib.at.

Post doctoral position on Development of a metabolic model for Chinese Hamster Ovary cells

Position
Post doctoral position on Development of a metabolic model for Chinese Hamster Ovary cells

Deadline 15.05.2011
Ref.No. 09_2011
Apply to jobs@acib.at

The Austrian Centre of Biotechnology (ACIB, www.acib.at) in Vienna has a long term programme on optimization of Chinese Hamster Ovary cells and their use in biotechnological production of therapeutic proteins. In the current project a model should be developed on the metabolism of these important cells that can be used for rapid process and media development by the industry.

The appropriate candidate should have a background in biotechnology, analytical chemistry, animal cell culture technology and / or modeling.

Please send your application documents (inlcuding reference number) via e-mail to jobs@acib.at.